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These are laboratory research observations only and do not represent established effects in humans or animals
Unlike exogenous GH administration which bypasses the pituitary entirely and suppresses endogenous GH production via negative feedback on the hypothalamic-pituitary axis MK-677 recruits the endogenous pituitary machinery, theoretically preserving somatostatin-mediated feedback regulation
This cascade promotes lipolysis (fat breakdown), protein synthesis, and favorable metabolic shifts
No human trial has established a best time, meal rule, or split schedule
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