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Using both genetic and pharmacological inhibition, our work is consistent with these data in that linagliptin retained the ability to improve glucose tolerance in animals devoid of all Gcg peptides
These modifications occur at four key positions: position 2 prevents DPP-IV cleavage, position 8 reduces asparagine rearrangement, position 15 enhances bioactivity, and position 27 prevents methionine oxidation
Gaddy, David M
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