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On GD12.5, the dams were weighed and were divided into two groups: one received an intraperitoneal (i.p.) injection of 600 mg/kg of VPA (Sigma-Aldrich, St
Central to this concept linking neural and systemic functions is the concept of allostasis (adaptation) and allostatic load/overload (pathophysiology) [6] that emphasizes the role of endogenous mediators for adaptation in contributing to pathologies, including MDD, when activated persistently or dysregulated under circumstances of toxic stress and health-damaging behaviors (poor diet, excessive alcohol consumption, sleep deprivation and circadian disruption)
Presented for research literature review only Schlenzig JS et al
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