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Recently, novel drugs combining GLP-1R agonism with other options, beyond the forementioned dual or triple agonist drugs, are being developed to maximize efficacy and minimize adverse effects in obesity and diabetes treatment

However, while these benefits are promising, we must also consider the reality of discontinuation and the potential for weight regain

In recent years, it has become increasingly recognized that ferroptosis may hold a pivotal position in OA, as its distinctive iron-dependent lipid peroxidation mechanism offers a unique explanation for the link between local inflammation and iron overload ( Figure 1 )

Acyl-GIP abolished the avoidance effect of PYY in control GIPR AP-GFP animals but not in GIPR AP-KO animals (Fig