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Lu, S.C., et al., Insulin and Glucocorticoid Dependence of Hepatic Gamma-Glutamylcysteine Synthetase and Glutathione Synthesis in the Rat Studies in Cultured-Hepatocytes and Invivo

Additionally, in phase 2 studies in people with MASH and liver fibrosis, survodutide not only significantly improved liver steatosis, but also led to histologic improvement of MASH without worsening fibrosis in 4362% of participants, versus 14% with placebo [41]

In Phase 2 trials (the TRIUMPH-2 study involving 338 participants over 48 weeks), the 12 mg dose of Retatrutide produced an average weight loss of 24.2%