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You may notice symptoms only once those stores are substantially depleted

That said, signs or symptoms that you may be low in vitamin B12 include: fatigue pale skin headaches symptoms of depression stomach issues difficulty focusing or concentrating pain or inflammation in the mouth or on the tongue burning or pins and needles feeling in your hands or feet muscle cramps vision changes Learn more: Signs and symptoms of B12 deficiency

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In some people, the immune system creates blocking or binding antibodies that interfere with this transport, leading to cerebral folate deficiency (CFD) even when blood folate looks normal