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The anti-apoptotic effect on outer root sheath cells was significant at picomolar concentrations (Pyo et al., 2007)
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The TRIUMPH-4 Phase 3 trial in obesity with knee osteoarthritis later reported 28.7% mean weight loss at 68 weeks with retatrutide 12 mg/week, and identified a dose-related dysesthesia (nerve-tingling) signal in 8.8% of 9 mg and 20.9% of 12 mg patients (Bays et al., 2025)
However, they work in different ways in the body
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