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There is currently no effective cure, but the condition can be effectively managed through lifestyle changes, medications, and sometimes insulin therapy
Mice were assigned to respective study groups to comprehensively evaluate multiple medical weight loss approaches with various controls: 1) vehicle (Veh, sterile water) as control, 2) SEMA to induce weight loss using semaglutide, 2) WM-CR to induce weight loss by caloric restriction to match weight loss in SEMA, 3) continuous RETA to induce weight loss, or 4) short-term RETA to induce weight loss then regain, termed RETA withdrawal (RETA-w/d)
Fernandez, D., Bonilla, E., Mirza, N., Niland, B
This prolonged transit time allows more water absorption from stool in the colon, resulting in harder, drier stools that are difficult to pass
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