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Site rotation (abdomen, thighs, upper arms) is the commonly reported approach to reduce this reaction

Xiao C, Li X, Huang L et al (2023) Prevalence and molecular characteristics of polymyxin-resistant enterobacterales in a Chinese tertiary teaching hospital

This needle is only 8 mm in length and when the shot is given at a 30 degree or less, as is the technique taught, the effective length is only a small fraction of the original 8 mm length

While some users report enhanced local effects, the evidence for superiority over subcutaneous administration remains unclear, and complications including nerve irritation present greater concern