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Future Directions and Research Priorities Emerging Therapeutic Approaches Triple agonist retatrutide and combinations including cagrisema have progressed to phase 3 trials as obesity treatments with early data suggesting even greater weight loss than tirzepatide [83]
In vivo experiments have shown that mice on a high-fat diet (HFD) treated with liraglutide displayed reduced concentrations of pro-inflammatory cytokines, such as interferon-gamma (IFN-) and IL-17, IL-22
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