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Back to Journals Diabetes, Metabolic Syndrome and Obesity Volume 15 The Relationship Between the Blood-Brain-Barrier and the Central Effects of Glucagon-Like Peptide-1 Receptor Agonists and Sodium-Glucose Cotransporter-2 Inhibitors Authors Dong M , Wen S , Zhou L Received 21 May 2022 Accepted for publication 12 August 2022 Published 22 August 2022 Volume 2022:15 Pages 25832597 DOI Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 3 Editor who approved publication: Professor Ming-Hui Zou Meiyuan Dong, 1 Song Wen, 1 Ligang Zhou 1, 2 1 Department of Endocrinology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, 201399, Peoples Republic of China

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However, each discontinuation carries the risk of weight regain, increased appetite, and potential negative metabolic shifts