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ALS pathology involves degeneration of upper and lower motor neurons, misfolded protein accumulation (e.g., TDP-43), mitochondrial dysfunction, oxidative stress, neuroinflammation, and excitotoxicity [100]
For context, diarrhoea is reported in approximately 916% of patients taking semaglutide 2.4 mg (Wegovy) according to its UK Summary of Product Characteristics (SmPC, emc), and in a broadly similar range for tirzepatide (Mounjaro) per its UK SmPC
Kangana Ranaut shared a photo of viral girl Monalisa while highlighting the glamour industrys bias towards lighter skin tones
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