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For example, pyruvate kinase muscle isoform 2 (PKM2) inactivation can both attenuate the glucose flux to PPP and enhance folate metabolism to mediate NADPH generation
201204 ALDH2 can inhibit the activation of NLRP3 inflammasome by reducing the excessive accumulation of mitochondrial ROS (mtROS) and total intracellular ROS, thereby mitigating high glucose-induced pyroptosis in cardiomyocytes
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