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The reconstituted solution remains stable at 28C for up to 28 days, after which peptide degradation accelerates regardless of storage conditions
In May 2023, FDA oversaw a nationwide recall of subpotent tirzepatide made by a compounder in Houston,25 and a second, nationwide recall of mislabeled tirzepatide made by the same Houston compounder in May 2024.26 In November 2024, FDA issued an urgent warning that a compounder in California had sold supposedly sterile injections containing a visible black particulate.27 In Custom Compounding (Mar
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Metformin, a first-line T2DM treatment, affects the gastrointestinal tract by altering glucose uptake, GLP-1 secretion, gut microbiota, and immune response [33, 34], but it rarely causes bowel obstruction
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