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This is generally considered the rate-limiting stage of glutathione synthesis

Reconstitution of TRAF3 in human multiple myeloma cell lines inhibited ChoK expression, suppressed the Kennedy pathway, and induced apoptosis, underscoring the role of elevated choline metabolism in sustaining the phenotype of TRAF3-deficient malignant B cells

2014;41(5):41523 ( quiz E1-2 )

In a study of 145 healthy subjects who were randomized to receive a placebo or 4 grams of Tylenol daily for two weeks, subjects in the placebo group experienced no elevations of ALT, a liver enzyme, but 33%-44% of the subjects in the Tylenol group had ALT elevations greater than three times the upper limits of normal