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Horinouchi H, Cho BC, Camidge DR, Goto K, Tomasini P, Li Y, et al
This dual agonist design distinguishes it from single-agonist GLP-1 analogues such as semaglutide and liraglutide
Microglia are transformed into DAM by recognizing Neurodegeneration-Associated Molecular Pattern (NAMP) danger signals which leak from damaged neuronal cells in analogy to the peripheral immune systems pathogen- and damage-associated stress signals (PAMPs and DAMPs) 23
Abnormal sperm morphology and an increase in malondialdehyde (MDA) levels were observed in the 10 mg/kg treatment group, whereas the changes were more pronounced in the 20 mg/kg treatment group, which exhibited a decrease in sperm counts, abnormal sperm morphology, DNA damage, degradation of cellular tubular structures, and elevated serum LH and testosterone levels
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