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Consistent with the reprotoxic effects of excessive lipolysis, long-term exposure to HFD in mice results in increased lipid droplet accumulation within oocytes and cumulusoocyte complexes (COCs), reduced mitochondrial membrane potential, upregulated ER stress markers (ATF4, GRP78), and increased apoptosis in granulosa cells, culminating in decreased ovulation and fertilization rates (Wu et al., 2010)

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Generalized linear models (GLZ) were used for data collected from free-ranging animals to assess relationships between each oxidative status marker and the predictor variables herpes infection (positive and negative) and species (khulan and zebra), as well as their interaction

No published monotherapy pharmacokinetic dataset exists