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the label also warns that rash, hives, or swelling of the face, mouth, lips, or tongue can signal a hypersensitivity reaction requiring emergency care, though no generalized allergic reactions were documented in the original trials Because current supply comes only from compounded preparations rather than an FDA-verified finished product, potency, purity, and sterility can vary by pharmacy, and unregulated online sources carry added contamination or mislabeling risk

(2025) discovered that Talaromyces purpurogenus , enriched in the gut of PCOS patients, produces the metabolite AT-C1, which suppresses the AhR signaling pathway and reduces IL-22 secretion, thereby inducing PCOS-like symptoms (69)

Kuijper IA, Yang H, Van De Water B, Beltman JB