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Higher doses of retatrutide resulted in greater weight loss
They share similar neurologic underpinnings, mostly related to the dopamine reward pathway, and both are influenced by hormones like ghrelin, orexin, and melanocortin that regulate food intake and reinforce drugs of abuse
Therefore, to safely harness the attractive catabolic and thermogenic effects of glucagon for treating metabolic disease, a counter-balancing therapy that selectively opposes the risk for glucagon-induced hyperglycaemia is required
Emerging research also indicates that GLP-1RAs can directly influence skeletal muscle function
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