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Although prevalence estimates vary according to diagnostic criteria, the global prevalence of SO among adults aged 60 years and older has been reported 11% [3]
10.3390/nu14102103 146
That is a treatment difference of 12.4 percentage points
It was first characterized by Predrag Sikiric and colleagues at the University of Zagreb in the early 1990s, and a 2025 literature and patent review cataloged its effects across gastrointestinal, musculoskeletal, and neural models
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