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Clinical studies report that they are helpful for cases of irritable bowel syndrome, Crohns disease, and, in the case of Lactobacillus plantarum, even Clostridium difficile infection in critically ill patients.62-66 Interestingly, Lactobacillus plantarum was recently found to degrade bisphenol A (BPA) and has been proposed as one way to remediate the contamination of foods due to plastics.67 Lactobacillus species also reduce oxidative stress in the gut through transcription factors nuclear factor erythroid 2-related factor 2 (Nrf-2) and nuclear factor kappa B (NF-B) and may protect intestinal epithelial cells.68 And in addition to digestion-related concerns, a clinical study reported 75 percent of participants saw alleviation of menopause symptoms according to the Simplified Menopause Index (SMI) scale after supplementing with Lactobacillus gasseri .69-71 But the fact remains that circulating estrogen levels are affected by the gut microbiota and the actions of beta-glucuronidase
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