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The crosstalk between Nrf2 and AMPK signal pathways is important for the anti-inflammatory effect of berberine in LPS-stimulated macrophages and endotoxin-shocked mice
Such pathophysiological complexity underscores the need for region-specific prevention strategies addressing this persistent global health burden
It is the leading cause of irreversible blindness globally, with projections indicating it could affect over 100 million individuals by 2040 (74)
This may indicate inadequate treatment intensity or an alternative neurological condition
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