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Large-scale trials like the Women's Health Initiative (WHI) demonstrate that a 5% or greater weight loss is associated with a 12% reduction in obesity-associated cancers (HR, 0.88

Current evidence supports indefinite use for patients who tolerate the medication well and continue to benefit from it

However, Fischer showed that leptin may increase energy expenditure by inducing a pyrexic increase in body temperature by reducing heat loss, rather than affecting BAT thermogenesis (Fischer et al., 2016)

Discussion To our knowledge, this study represents the first human laboratory investigation of the effects of cannabis administration, via different routes (i.e., oral, smoked, and vaporized), on peripheral concentrations of appetitive and metabolic hormones in a sample of occasional and frequent cannabis users