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Medication adherence issues can substantially impair effectiveness
By contrast, Trulicitys AWARD-11 trial showed the highest dose (4.5 mg) produced a weight reduction of approximately 4.7 kg (~10.4 lbs) at 36 weeks-a modest but clinically meaningful secondary benefit for patients primarily managing type 2 diabetes
Abrupt discontinuation is generally discouraged, as gradually tapering the dose can help minimize rebound appetite and reduce blood sugar instability
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