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For example, Withaferin A and FINO2 induce ferroptosis by inhibiting GPX4 and changing iron metabolism, respectively ( 1.3.1.2 Targets small molecules and drug inducers of GSH/GPX4 axis and FSP1/CoQ related pathways Some tumors have failed the pathway of sulfur transfer due to mutation or apparent modification, so tumor cells are highly dependent on System Xc- for cystine uptake, and System Xc- has become an important target of anti-tumor drugs ( Table 1
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To calculate the total amount of lyophilized peptide for a treatment cycle, return to the second section and input the cycle length
Cellular senescence in ageing: from mechanisms to therapeutic opportunities
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