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The first pertained to physical health effects, with participants reporting an overall positive experience of taking the medication, finding that the improvements in weight and blood glucose control outweighed the gastrointestinal side effects

Zhang W, Nuki G, Moskowitz RW, Abramson S, Altman RD, Arden NK, Bierma-Zeinstra S, Brandt KD, Croft P, Doherty M, Dougados M, Hochberg M, Hunter DJ, Kwoh K, Lohmander LS, Tugwell P (2010) OARSI recommendations for the management of hip and knee osteoarthritis: part III: changes in evidence following systematic cumulative update of research published through January 2009

Drug repurposing: progress, challenges and recommendations