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From a pricing perspective, oral formulations can introduce distinct starter tiers and distribution channels that potentially undercut higher-cost injectables, with public discussions citing starter oral pricing examples in reduced-tier programs
Regarding cardiovascular outcomes, the EXSCEL trial showed that exenatide extended-release was noninferior but not superior to placebo for major adverse cardiovascular events
In a way, apomorphine was a predecessor concept to PT-141: a centrally-acting ED drug
At this stage, refrigeration is mandatory
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