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Patients with high VEGF-C expression were related to a short PFS (Sopo et al., 2019)
Damage to the lining of the stomach and small intestine results in symptoms that range from relatively minor heartburn, nausea, and abdominal pain (affecting 15-40% of NSAID users) to the life-threatening ulceration, perforation, and bleeding (affecting 1-2% of chronic NSAID users) (Vonkeman 2010)
Adding fasting to gastroparesis creates risk of food remaining in the stomach across fasting periods, contributing to nausea, vomiting, and nutrient malabsorption
Because these drugs affect your digestive system, a gradual titration schedule helps minimize side effects, such as nausea, while moving toward a maintenance dose
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