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Regulated necrosis: disease relevance and therapeutic opportunities
Prescribers should still exercise caution with any GH-axis stimulation in patients with liver disease, given GH's effects on hepatic glucose metabolism and IGF-1 production
Additionally, administration or overexpression of FGF21 reduces blood pressure in various preclinical models of hypertension (316318)
Tirzepatide activates both the GIP receptor (GIPR) and the GLP-1 receptor (GLP-1R), both class B GPCRs, though with differential potency
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