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In the present study, cholesterol-induced suppression on AMPK phosphorylation and ABCA1 protein expression could indeed be attenuated by GLP-1R agonist EX-4 and further abolished by AMPK activator AICAR while it is enhanced by AMPK inhibitor Compound C

In heart failure, expression of BCAA metabolic enzymes is regulated by transforming growth factor--activated kinase 1 (TAK1) and p38 MAPK signaling pathways, with downregulation of the transcription factor KLF15 leading to systemic decreased expression of BCAA metabolic enzymes (91)