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A structured roadmap for clinical translation From a translational perspective, microbiome-based stratification cannot be recommended as a routine clinical tool due to limited human evidence, methodological heterogeneity, absence of standardized analytical pipelines, and lack of validated microbial cut-offs
Within the main cohort of approximately 2,000 participants, two baskets were enrolled based on obesity-related comorbidities: 574 participants with knee osteoarthritis and 243 with obstructive sleep apnea (OSA)
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