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Because of the difficulties many people face in maintaining weight loss, lifelong treatment may be needed
It's important to note that GLP-1 secretion is also integrated with neural and hormonal signalling beyond direct nutrient sensing
79 While the direct renoprotective mechanisms of GLP-1RAs are still under investigation, their ability to enhance natriuresis and suppress pathogenic angiotensin II production presents a valuable therapeutic strategy in HFpEF complicated by CKD
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