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By mimicking the signaling of natural GHRH, it encourages the pituitary to release a more youthful pulse of growth hormone
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ECM-based biomarkers reflecting MMP-9 activity, such as C3M (MMP-9 mediated degradation of type III collagen) and C4M (MP-2, 9, 12 mediated degradation of type IV collagen), are significantly elevated in Hurley stages II and III of HS and show a moderate-strong correlation with the IHS score, indicating their utility in assessing disease activity and severity [104] (Table 1, Fig
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