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163 CYP450 enzymes in the liver regulate the metabolism of many anticancer drugs (e.g., imatinib and erlotinib), and altered activity can lead to reduced efficacy or increased toxicity
Even those with some research backing them have primarily been studied in pill form
NICE criteria include BMI 40 kg/m or 35 kg/m with comorbidities, with consideration for BMI 30-34.9 kg/m with recent-onset type 2 diabetes and lower thresholds for some ethnic groups
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