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White AT (WAT) in obese tissue has been observed to increase the number of macrophages and mast cells compared to lean tissue leading to increased gene expression of TNF- and a remarkable increase in IL-6 and iNOS levels (25, 28)

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A spokesperson for Eli Lilly previously said in a statement: "Retatrutide is an investigational, once-weekly, triple hormone receptor agonist, which activates the body's receptors for glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), and glucagon