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These incretin-based medications work by mimicking naturally occurring hormones that enhance insulin secretion, suppress glucagon release, slow gastric emptying, and reduce appetite through central nervous system pathways
There is limited research, but most users experience weight loss after a few weeks to a few months
However, its effects on hormones and metabolic processes can lead to other physiological changes, some of which may impact sexual health
The STEP 4 trial demonstrated that participants who discontinued semaglutide after 20 weeks regained approximately two-thirds of lost weight over the next 48 weeks
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