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That having been said, patients who are responding well to the high doses want to stay on the high doses, he said

Pernicious anemia occurs more commonly in people who already have diseases that are linked to immune-system abnormalities, such as Graves disease, hypothyroidism (under-functioning thyroid gland), thyroiditis (inflammation of the thyroid), vitiligo, and Addison's disease (adrenocortical insufficiency)

Proper documentation, storage and handling practices help maintain sample integrity throughout research activities

Chandys hypothesis is accurate, the initial worsening might be a sign that the body is starting to heal or correct imbalances that have been present for a long time