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The hypothalamic-pituitary-adrenal (HPA) axis function often changes with chronic psychological stress, sleep deprivation, and depressionconditions themselves linked to weight gain and metabolic disease
Submission of the drug for FDA approval for weight loss is expected after completion of a second phase 3 trial, SURMOUNT-2, in spring 2023
It may be useful when allergies or histamine symptoms occur with chronic depression, OCD traits, perfectionism, inner tension or unusual reactions to methylation supplements or psychiatric medications
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