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Bai R, Guo J, Ye X-Y, Xie Y, Xie TJA

Additionally, damaged mitochondria release mtDNA into the cytosol, activating the innate immune system via damage-associated molecular patterns (DAMPs) (251, 377), modulating both innate and adaptive immune responses (377379)

Consistently, DMF significantly induced the expression of antioxidant proteins such as Nqo1 and Gpx4, which are critical for detoxification reaction and GSH utilization (Fig