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As shown in Scheme 16
Finally, we expressed H188 in HEK293 cells by viral transduction to demonstrate that soluble adenylyl cyclase (sAC) activity could be monitored in FRET assays that compared wild-type (WT) HEK293 cells or HEK293-sAC cells treated with IBMX in the presence or absence of the selective sAC inhibitor LRE1 (Fig
I., Finkelstein, D
The indirect includes correction of SCFAs and dysbiosis, which may contribute to the BBR activity in vivo
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