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The sequence Gly-His-Lys binds copper(II) ions through a coordination complex involving the histidine imidazole nitrogen, the terminal amino group, and the deprotonated amide nitrogen of the Gly-His peptide bond
Niyazov, D
That is measured by an elemental technique, inductively coupled plasma mass spectrometry or atomic absorption spectroscopy, not by chromatography, and a certificate reporting only peptide purity has not established that the material is a complex at all rather than a peptide with some copper alongside it
Research on these peptides is also contributing to a deeper understanding of angiogenesis, cell migration, vascular signaling, and regenerative processes, which may ultimately support the development of future therapeutic strategies
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