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Intrinsic factor, a protein that shuttles B12 through the absorption process, becomes saturated after a meal containing an above-average amount of B12 and about 4 to 6 hours are required before it can efficiently absorb another dose (IOM, 1998)
The FDA guidance on subcutaneous peptide formulations acknowledges this source of pharmacokinetic variability
The Cochrane Collaboration, Chichester, UK: John Wiley & Sons
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