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Supplements with no clear evidence of benefit Symptoms of thiamin (vitamin B-1) deficiency are similar to some symptoms of fibromyalgia, and low levels of thiamin have been linked with fibromyalgia
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This article compares mechanism, Phase 2 trial design, reported efficacy, tolerability signals, and research-use status
In multiple rodent models of chronic stress (a shared risk factor for major psychiatric illnesses), administration of LAC leads to a rapid and persistent antidepressant-like response by increasing histone acetylation and expression of key genes, including mGlu2 receptors and the downstream brain-derived neurotrophic factor BDNF [27, 30, 34,35,36,37]
