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Most GLP-1 receptor agonists (except exenatide formulations) carry an FDA boxed warning regarding thyroid C-cell tumors observed in rodent studies and are contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)
Other compounds try to mimic exercise through different mechanisms
doi: 10.1210/en.2011-1864 67 van den BrinkWEmerencianaABellantiFDella PasquaOvan der LaanJW
One filing referenced distributors listing the drug as out-of-stock or available only in limited quantities, suggesting gaps in the supply chain despite the FDAs confidence in Eli Lillys manufacturing capacity
