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Gene therapies targeting pathogenic GBA variants are addressed in the section Glucocerebrosidase targeting therapies

Preclinical work demonstrates incretin receptor gene and protein expression in female reproductive tissues such as ovary and uterine structures in animal models, supporting the concept that incretin signalling can interact with reproductive physiologyagain, not equivalent to a clinically meaningful direct vaginal mucosal effect in humans

For many people, these medications dramatically improve blood sugar, reduce cardiovascular risk, and promote weight loss , which can be life-saving

Six months and beyond: For those looking for more significant brightening, this is the timeframe where deep-seated pigment changes typically become visible