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Throughout this review, emphasis has been placed on transparent acknowledgment of uncertainty, careful grading of evidence, and explicit identification of translational gaps
The medication is still active, but the environment in which it's working has shifted
The two latest meta-analyses do not prove the hypothesis that acetyl-l-carnitine exerts a positive effect on chemotherapy-induced polyneuropathy [69, 77], and its use is not recommended by the ASCO guidelines [76]
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