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The guiding principle from clinical data is clear: escalate every four weeks, starting from the lowest effective dose, and never increase if side effects from the current dose have not stabilized

Concerns regarding a link between GLP-1 and the more common papillary thyroid carcinoma (PTC) have also been raised as cells of this lineage do express GLP-R more than normal thyroid tissue 51 although evidence that the use of these drugs in humans causes increased cellular proliferation is not conclusive