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After 12 weeks, the researchers noted that the group receiving L-carnitine did indeed show improvements in fatigue, with the most significant improvements seen in brain fatigue. The most significant results were in those younger than 50, those over the age of 50 with high levels of free T3, and those who had hypothyroidism due to a thyroidectomy (who were taking relatively high doses of thyroid hormone)
In a phase 1b placebo-controlled, randomized clinical trial, participants with overweight or obesity received OW SC cagrilintide at various doses or placebo, in conjunction with semaglutide 2.4 mg over 20 weeks [123]
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