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The reduced NRF2 levels we observed might therefore represent an adaptive response to sustained oxidative stress rather than a primary defect

BMC Public

Free Radic Biol Med 40:19601970 Martin E, Rosenthal RE, Fiskum G (2005) Pyruvate dehydrogenase complex: metabolic link to ischemic brain injury and target of oxidative stress

For instance, the release of damage-associated molecular patterns (DAMPs) such as HMGB1 during ferroptosis activates receptors like AGER/RAGE, stimulating the NF-B pathway (Wen et al., 2019)