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Interactions with Medications and Substances Alcohol and Caffeine: Regular consumption of alcohol may interfere with the body's ability to absorb vitamin B12, potentially diminishing the efficacy of the injection and leading to suboptimal relief from deficiency symptoms

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Serious Indicators of Vitamin B-12 Deficiency Severe vitamin B12 deficiency can cause signs and symptoms such as Yellow skin Weak muscles Numb or tingly hands or feet Trouble walking Severe joint pain Increasing shortness of breath Weight loss Irritability Lack of smell and taste sensations Memory loss Paranoia Delusions Deep depression What Does B12 Fatigue Feel Like

But those studies, McGuire says, dont have a lot of evidence behind them, and if you look on Reddit or other places where people are talking about it, he says, it appears that most people are recommending repeated doses